Anesthetics and Inflammation Resolution
Author Information
Author(s): Chiang Nan Schwab, Jan M. Fredman, Gabrielle Kasuga, Kie Gelman, Simon Serhan, Charles N. Serhan
Primary Institution: Brigham and Women's Hospital and Harvard Medical School
Hypothesis
Do local and volatile anesthetics impact the resolution of inflammation?
Conclusion
Lidocaine delays the resolution of inflammation while isoflurane promotes it.
Supporting Evidence
- Lidocaine increased leukocyte accumulation and delayed PMN apoptosis.
- Isoflurane reduced leukocyte infiltration and shortened the resolution interval.
- Lidocaine did not significantly alter levels of specific lipid mediators.
- Addition of lipoxin A4 stable analog partially rescued lidocaine-delayed resolution.
- Proteomics revealed distinct protein regulation by lidocaine and isoflurane.
Takeaway
Some medicines used during surgery can help or hurt the body's healing process after an injury.
Methodology
Mice were treated with lidocaine or isoflurane during induced inflammation, and various cellular and molecular responses were measured.
Potential Biases
Potential bias in the interpretation of results due to the specific anesthetics used.
Limitations
The study was conducted in mice, which may not fully represent human responses.
Participant Demographics
Male FVB mice, 6-8 weeks old.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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