Massive acute intravascular hemolysis after platelet transfusion: An unrecognized entity
2011
Massive Acute Intravascular Hemolysis After Platelet Transfusion
publication
Evidence: low
Author Information
Author(s): Vishakha Jain, K. V. Kamesh, Sambasivaiah S.
Primary Institution: Mahatma Gandhi Institute of Medical Sciences
Hypothesis
Can acute intravascular hemolysis occur after transfusion of ABO-mismatched platelets?
Conclusion
Acute hemolytic reactions can occur after transfusion of ABO-mismatched platelets, leading to severe complications and even death.
Supporting Evidence
- Acute hemolytic reactions after platelet transfusions are rarely encountered but can be fatal.
- The patient experienced severe symptoms including fever, jaundice, and red colored urine after receiving unmatched platelets.
- Direct antiglobulin test was positive, indicating hemolysis.
- Transfusion of ABO-mismatched platelets is common when specific platelets are unavailable.
Takeaway
Sometimes, when people get blood platelets that don't match their blood type, it can make them very sick and even cause them to die.
Methodology
Case report of a patient who experienced acute hemolysis after receiving unmatched platelet transfusions.
Limitations
The case is based on a single patient, limiting generalizability.
Participant Demographics
49-year-old female, B Rh positive blood group.
Digital Object Identifier (DOI)
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