Gene Expression Signature of Cigarette Smoking and Its Role in Lung Adenocarcinoma Development and Survival
Author Information
Author(s): Landi Maria Teresa, Dracheva Tatiana, Rotunno Melissa, Figueroa Jonine D., Liu Huaitian, Dasgupta Abhijit, Mann Felecia E., Fukuoka Junya, Hames Megan, Bergen Andrew W., Murphy Sharon E., Yang Ping, Pesatori Angela C., Consonni Dario, Bertazzi Pier Alberto, Wacholder Sholom, Shih Joanna H., Caporaso Neil E., Jen Jin
Primary Institution: National Cancer Institute, National Institutes of Health (NIH)
Hypothesis
What are the molecular alterations induced by smoking in lung tissue that develop into cancer and impact survival?
Conclusion
The study identifies a gene expression signature related to smoking that persists after cessation and is linked to lung cancer development and survival.
Supporting Evidence
- The study analyzed 135 tissue samples from current, former, and never smokers.
- Gene expression changes were confirmed in independent adenocarcinoma and non-tumor tissues.
- Smoking-related gene expression alterations persisted many years after cessation.
Takeaway
Smoking changes the genes in your lungs, which can lead to cancer and affect how long you live after being diagnosed.
Methodology
Gene expression analysis using HG-U133A Affymetrix chips on fresh frozen tissue samples from smokers and non-smokers.
Potential Biases
Potential bias due to self-reported smoking status and sample selection.
Limitations
The study may not account for all confounding factors affecting gene expression.
Participant Demographics
Subjects aged 44–79 years with histologically confirmed primary adenocarcinoma of the lung.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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