Melasma and Its Association with Nevi in Women
Author Information
Author(s): Adalatkhah Hassan, Sadeghi-bazargani Homayoun, Amini-sani Nayereh, Zeynizadeh Somayeh
Primary Institution: Ardabil University of medical sciences
Hypothesis
Is there an association between melasma and the existence of different kinds of nevi?
Conclusion
Existence of lentigines and melanocytic nevi increases the chance of having melasma.
Supporting Evidence
- Mean number of lentigines was 25.5 in the melasma group compared to 8 in the control group.
- Mean number of melanocytic nevi was 13.2 in cases compared to 2.8 in the control group.
- The chance of melasma increased up to 23 times for patients having more than three melanocytic nevi.
Takeaway
Women with more freckles and certain types of moles are more likely to have melasma, which is a skin condition that causes dark patches on the face.
Methodology
A case-control study comparing 120 female melasma patients with 120 controls matched for age.
Potential Biases
Potential selection bias due to the nature of case-control studies.
Limitations
Selection bias is a concern, and the study's retrospective design limits causal inferences.
Participant Demographics
All participants were female, with a mean age of approximately 30 years, mostly urban residents.
Statistical Information
P-Value
p<0.001
Confidence Interval
95% CI of OR for above 3 melanocytic nevi: 9.7 – 54.7
Statistical Significance
p<0.01
Digital Object Identifier (DOI)
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