Serotonin Transporter Binding in Bulimia Nervosa
Author Information
Author(s): Koskela Anu K, Keski-Rahkonen Anna, Sihvola Elina, Kauppinen Tomi, Kaprio Jaakko, Ahonen Aapo, Rissanen Aila
Primary Institution: Helsinki University Central Hospital
Hypothesis
We hypothesized clearly reduced SERT binding in BN women as opposed to healthy women, and intermediate SERT binding in unaffected co-twins.
Conclusion
Increased SERT binding in the midbrain in purging BN women suggests they might differ in serotonergic function from non-purging ones.
Supporting Evidence
- Bulimia Nervosa is linked to genetic and environmental factors.
- Previous studies indicated disturbances in serotonin transmission in bulimia.
- The study found no significant differences in SERT binding between bulimic women and healthy controls.
Takeaway
The study looked at brain chemicals in women with bulimia and found that those who purge have different brain activity compared to healthy women.
Methodology
The study used SPET imaging with the radioligand [123I]ADAM to assess SERT binding in 13 bulimic women and 25 healthy controls.
Potential Biases
Potential confounding factors include the inclusion of subjects with past histories of major depression and anorexia.
Limitations
The small sample size limits the reliability of the findings.
Participant Demographics
Participants included 13 women with bulimia nervosa and 25 healthy women, including twin sisters.
Statistical Information
P-Value
0.03
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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