Myopenia and Body Fat Distribution in Ulcerative Colitis Patients
Author Information
Author(s): Wei Wei, Yan Pengguang, Zhang Yan, Wang Qiong, Kang Junren, Liu Pengju, Fu Jin, Li Jingnan, Yu Kang
Primary Institution: Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
Hypothesis
This study aimed to investigate the prevalence of myopenia in hospitalized patients with active ulcerative colitis and its impact on therapeutic response.
Conclusion
The study found that nearly 50% of hospitalized ulcerative colitis patients had myopenia, which is associated with a poorer clinical response to vedolizumab treatment.
Supporting Evidence
- The prevalence of myopenia was found to be 49.7% in the cohort.
- Myopenia was significantly associated with a lower clinical response rate to vedolizumab.
- Patients with myopenia had lower serum albumin and higher hsCRP levels.
- Visceral obesity tended to diminish the clinical response rate but did not reach statistical significance.
Takeaway
Almost half of the patients with ulcerative colitis in the hospital have low muscle mass, which can make their treatment less effective.
Methodology
A retrospective cohort study using CT scans to measure body composition in hospitalized patients with active ulcerative colitis.
Potential Biases
The study's retrospective nature may introduce selection bias.
Limitations
The study may overestimate myopenia prevalence as patients needing CT scans may have more severe disease manifestations.
Participant Demographics
457 hospitalized patients aged 18 to 70 with active ulcerative colitis, including 254 males and 203 females.
Statistical Information
P-Value
0.018
Confidence Interval
95% CI 1.238–9.659
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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