6-Chloro-2-cyclopropyl-4-(trifluoromethyl)quinoline
2011
Crystal Structure of a New Quinoline Derivative
publication
Evidence: moderate
Author Information
Author(s): Devarajegowda H. C., Arunkashi H. K., Vepuri Suresh Babu, Chidananda N., Prasad V. D. Jagadeesh
Primary Institution: University of Mysore
Hypothesis
The newly designed hybrid molecule would exhibit some antibacterial activity.
Conclusion
The study successfully reports the crystal structure of 6-chloro-2-cyclopropyl-4-(trifluoromethyl)quinoline.
Supporting Evidence
- The quinoline ring system makes a dihedral angle of 88.8° with the cyclopropyl ring.
- Bond distances and angles in the quinoline ring are consistent with related structures.
- The study provides a detailed crystal structure analysis of the compound.
Takeaway
Scientists made a new chemical compound and looked at its structure to see if it could help fight germs.
Methodology
The compound was synthesized using a mixture of cyclopropyl acetylene, zinc(II), triethylamine, and toluene, followed by purification through column chromatography.
Digital Object Identifier (DOI)
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