Potassium Channel Gene Mutations and Atrial Fibrillation
Author Information
Author(s): Ellinor Patrick T, Petrov-Kondratov Vadim I, Zakharova Elena, Nam Edwin G, MacRae Calum A
Primary Institution: Cardiovascular Research Center and Cardiac Arrhythmia Service Massachusetts General Hospital, Boston, Massachusetts
Hypothesis
Are mutations in KCNJ2 and KCNE1-5 a common cause of atrial fibrillation?
Conclusion
Mutations in KCNJ2 and KCNE1-5 rarely cause typical atrial fibrillation in a referral clinic population.
Supporting Evidence
- The study screened 96 patients with familial atrial fibrillation.
- No mutations were detected in the potassium channel genes KCNJ2 and KCNE1-5.
- The mean age at onset of atrial fibrillation was 46 years.
Takeaway
The study looked at patients with a family history of atrial fibrillation to see if certain gene mutations were causing it, but they found that these mutations are not common.
Methodology
Patients with lone atrial fibrillation or atrial fibrillation with hypertension were screened for mutations in potassium channel genes.
Limitations
The cohort may not represent all patients with lone atrial fibrillation and was predominantly of Northern European descent.
Participant Demographics
Mean age of participants was 56 years, with 81% having paroxysmal atrial fibrillation.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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