NTRK1 Gene Rearrangements in Thyroid Tumors After Radiation
Author Information
Author(s): Bounacer A, Schlumberger M, Wicker R, Du-Villard J A, Caillou B, Sarasin A, Suárez H G
Primary Institution: Institut Gustave Roussy
Hypothesis
Does the NTRK1 gene play a role in radiation-induced thyroid carcinogenesis?
Conclusion
The study found that NTRK1 rearrangements occur at a similar frequency in radiation-associated and spontaneous thyroid tumors, indicating a minor role in radiation-induced papillary thyroid carcinomas.
Supporting Evidence
- NTRK1 rearrangements were detected in 2 out of 14 papillary carcinomas and one lymph-node metastasis.
- All radiation-associated adenomas were negative for NTRK1 rearrangements.
- The frequency of NTRK1 rearrangements was 6% in both radiation-associated and spontaneous thyroid tumors.
Takeaway
The researchers looked at thyroid tumors from patients who had radiation treatment and found that a specific gene rearrangement happens in some of these tumors, but not in all.
Methodology
The presence of NTRK1 rearrangements was investigated using reverse transcription polymerase chain reaction, Southern blot, and direct sequencing techniques.
Participant Demographics
Patients who had received external radiation and those without a history of radiation exposure.
Digital Object Identifier (DOI)
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