How Neurog2 Cells Create Olfactory Bulb Neurons
Author Information
Author(s): Winpenny Eleanor, Lebel-Potter Mélanie, Fernandez Maria E, Brill Monika S, Götz Magdalena, Guillemot Francois, Raineteau Olivier
Primary Institution: Cambridge Centre for Brain Repair
Hypothesis
Neurog2-positive precursor cells sequentially generate different types of glutamatergic neurons in the olfactory bulb.
Conclusion
The study reveals that Neurog2-positive progenitors give rise to various subtypes of glutamatergic neurons in the olfactory bulb at different developmental stages.
Supporting Evidence
- Neurog2-positive progenitors generate all subtypes of glutamatergic neurons in the olfactory bulb.
- Mitral and tufted cells are produced at early embryonic stages.
- Juxtaglomerular neurons are generated at later embryonic and perinatal stages.
- Most juxtaglomerular neurons express T-Box protein Tbr2, while those generated later also express Tbr1.
- A small portion of OB glutamatergic neurons originate from extrabulbar regions.
Takeaway
Some special cells in the brain called Neurog2 cells help make different types of neurons that help us smell, and they do this at different times as the brain grows.
Methodology
The study used inducible genetic fate mapping to track Neurog2-positive progenitors and their progeny in the olfactory bulb.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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