Cyclooxygenase-2 overexpression correlates with tumour recurrence, especially haematogenous metastasis, of colorectal cancer
2000
COX-2 and Colorectal Cancer Recurrence
publication
Author Information
Author(s): Tomozawa S, Tsuno N H, Sunami E, Hatano K, Kitayama J, Osada T, Saito S, Tsuruo T, Shibata Y, Nagawa H
Primary Institution: Department of Surgical Oncology, Graduate School of Medical Sciences, University of Tokyo
Hypothesis
Does COX-2 overexpression correlate with tumor recurrence in colorectal cancer?
Conclusion
High COX-2 expression is significantly associated with tumor recurrence and haematogenous metastasis in colorectal cancer.
Supporting Evidence
- COX-2 expression was mainly found in the cytoplasm of cancer cells.
- Patients were divided into high- and low-COX-2 expression groups.
- High-COX-2 expression significantly correlated with tumour recurrence.
- The study suggests COX-2 inhibitors could be a new treatment for colorectal cancer.
Takeaway
This study found that when cancer cells have a lot of COX-2, the cancer is more likely to come back and spread to other parts of the body.
Methodology
Immunohistochemistry was used to examine COX-2 expression in advanced human colorectal cancer.
Digital Object Identifier (DOI)
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