Effects of Artichoke Bract Extract on Lipid Metabolism Disorders
Author Information
Author(s): Mokhtari Imane, Shahat Abdelaaty A., Noman Omar M., Milenkovic Dragan, Amrani Souliman, Harnafi Hicham, Kawagishi Hirokazu, Barbalho Sandra
Primary Institution: Laboratory of Bioresources, Biotechnologies, Ethnopharmacology and Health, Faculty of Sciences, University Mohamed I, Oujda, Morocco
Hypothesis
This study aimed to investigate the effects of aqueous artichoke bract extract on lipid metabolism, liver antioxidative defense, and liver steatosis in mice fed a high-fat, high-sucrose diet.
Conclusion
The artichoke bract extract could be considered a natural resource of bioactive compounds to treat hyperlipidemia and related cardiometabolic diseases.
Supporting Evidence
- AE significantly improved plasma lipid profiles by reducing total cholesterol, triglycerides, and LDL–cholesterol while increasing HDL–cholesterol.
- AE facilitated cholesterol reduction in the liver and its excretion, indicating activation of reverse cholesterol transport.
- AE lowered MDA levels and enhanced antioxidant enzyme activities.
- AE was found to be safe with an LD50 greater than 5000 mg/kg.
Takeaway
This study found that artichoke extract can help lower bad cholesterol and improve liver health in mice that eat a lot of fat and sugar.
Methodology
An 8-week study used hyperlipidemic mice treated with aqueous artichoke bract extract at daily doses of 100 and 200 mg/kg bw, compared to fenofibrate.
Participant Demographics
Adult male albino mice weighing 24–26 g.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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