Oncogenic AKTivation of Translation as a Therapeutic Target
Author Information
Author(s): A C Hsieh, M L Truitt, D Ruggero
Primary Institution: University of California, San Francisco
Hypothesis
How oncogenic AKT activates ribosome biogenesis, translation initiation, and translational elongation to regulate these translational networks is an ongoing area of research.
Conclusion
Oncogenic AKT signalling enhances protein synthesis by regulating multiple stages of mRNA translation, making it a potential therapeutic target.
Supporting Evidence
- AKT regulates protein synthesis through the phosphorylation of multiple downstream targets.
- Oncogenic AKT drives tumor development by enhancing translation initiation and elongation.
- Targeting eIF4E, a key factor in translation initiation, may provide therapeutic benefits in cancer.
Takeaway
AKT is like a switch that helps cells make proteins, and when it's broken, it can cause cancer. Scientists are trying to find ways to turn off this switch to stop cancer.
Methodology
The review discusses the role of AKT in regulating protein synthesis through various mechanisms including ribosome biogenesis, translation initiation, and elongation.
Limitations
The review does not provide new experimental data but synthesizes existing knowledge on AKT's role in translation.
Digital Object Identifier (DOI)
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