Anti-Convulsant Activity of Boerhaavia diffusa
Author Information
Author(s): Mandeep Kaur, Rajesh Kumar Goel
Primary Institution: Punjabi University, Patiala, India
Hypothesis
The roots of Boerhaavia diffusa may possess anti-convulsant activity due to calcium channel antagonistic effect of liriodendrin.
Conclusion
The methanolic extract of Boerhaavia diffusa roots has anti-convulsant activity, primarily due to the presence of liriodendrin.
Supporting Evidence
- The crude methanolic extract of B. diffusa showed dose-dependent protection against PTZ-induced convulsions.
- The liriodendrin-rich fraction provided significant protection against seizures induced by BAY k-8644.
- Only the liriodendrin-rich fraction retained anti-convulsant activity, confirming its role in the observed effects.
Takeaway
This study found that a plant called Boerhaavia diffusa can help stop seizures, and it works because of a special ingredient in it called liriodendrin.
Methodology
The study involved extracting different fractions from Boerhaavia diffusa roots and testing their anti-convulsant effects in mice using pentylenetetrazol-induced seizures.
Limitations
The study did not explore the long-term effects of the extracts or their safety in humans.
Participant Demographics
Male Swiss albino mice, weighing 25–35 g.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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