5-Day Regional Chemotherapy with 5-Fluorouracil for Colon Cancer
Author Information
Author(s): J.-Louis Boublil, G. Milano, R. Khater, J. Bourry, A. Thyss, J.-N. Bruneton, N. Renee, C. Philip, M. Namer
Primary Institution: Centre Antoine Lacassagne
Hypothesis
How do different routes of administering 5-fluorouracil affect its pharmacokinetics in patients with colon carcinoma?
Conclusion
The intra-arterial hepatic and portal vein routes significantly improve drug delivery compared to the intra-arterial pelvic route.
Supporting Evidence
- 5-FU blood levels were measured every day for a total of 87 cycles.
- Both the i.a.h. and i.p.v. routes resulted in significant reductions in drug levels compared to the i.v. route.
- Increasing the dose led to a modification in circulating 5-FU levels proportional to the dose for the i.v. and i.a.p. routes.
- For the i.a.h. and i.p.v. routes, systemic drug delivery was significantly elevated, indicating a saturable process.
- Local extraction for the i.a.p. route was non-existent, showing no advantage over classical i.v. infusion.
Takeaway
Doctors gave a medicine called 5-FU to 18 patients in different ways to see which way worked best. They found that some ways helped the medicine work better.
Methodology
Patients received continuous 5-day infusions of 5-FU through different routes, and blood levels were measured daily.
Limitations
The small number of patients in the intra-arterial pelvic group limits the generalizability of the results.
Participant Demographics
18 patients (13 male, 5 female) with a mean age of 65 years.
Statistical Information
P-Value
P<0.001
Confidence Interval
(0.90-0.95)
Statistical Significance
p<0.001
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