Distinct Fibroblast Cluster Linked to Bladder Cancer Prognosis
Author Information
Author(s): Feng Chao, Wang Yaobang, Song Wuyue, Liu Tao, Mo Han, Liu Hui, Wu Shulin, Qin Zezu, Wang Zhenxing, Tao Yuting, He Liangyu, Tang Shaomei, Xie Yuanliang, Wang Qiuyan, Li Tianyu
Primary Institution: The First Affiliated Hospital of Guangxi Medical University
Hypothesis
The study investigates the spatial heterogeneity of the muscle-invasive bladder cancer microenvironment and its association with prognosis.
Conclusion
A specific fibroblast cluster in the bladder cancer microenvironment is associated with poor prognosis and increased angiogenesis.
Supporting Evidence
- The study identified a fibroblast cluster (S3) that is significantly associated with poor prognosis in muscle-invasive bladder cancer.
- S3-positive tumors exhibited increased blood vessel density and altered vascular morphology.
- Machine learning algorithms were used to establish a prognostic gene signature related to S3.
Takeaway
Researchers found a special group of cells in bladder cancer that can predict how well patients will do, showing that these cells help tumors grow new blood vessels.
Methodology
The study used imaging mass cytometry and single-cell RNA sequencing to analyze tissue samples from bladder cancer patients.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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