Lipoproteins Help Fight Salmonella Infections
Author Information
Author(s): Netea Mihai G., Joosten Leo A. B., Keuter Monique, Wagener Frank, Stalenhoef Anton F. H., van der Meer Jos W. M., Kullberg Bart Jan
Primary Institution: Radboud University Nijmegen Medical Center
Hypothesis
Do circulating lipoproteins improve resistance to Salmonella typhimurium infection?
Conclusion
Plasma lipoproteins are a potent host defense mechanism against invasive Salmonella infection by blocking adhesion of Salmonella to host cells and preventing tissue invasion.
Supporting Evidence
- LDLR−/− mice showed 100% survival compared to 5% in LDLR+/+ mice after Salmonella infection.
- Bacterial burden was significantly lower in LDLR−/− mice compared to LDLR+/+ mice.
- Lipoproteins were shown to block the adhesion of Salmonella to host cells.
Takeaway
Lipoproteins in the blood help protect against Salmonella infections by stopping the bacteria from sticking to and invading body tissues.
Methodology
The study used LDLR−/− and LDLR+/+ mice to assess survival and bacterial burden after Salmonella infection.
Participant Demographics
Mice used were homozygous C57Bl/6J, aged six to eight weeks.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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