Moringa Leaf Extract Helps Muscle Cells Recover from Oxidative Stress
Author Information
Author(s): Ceci Roberta, Maldini Mariateresa, La Rosa Piergiorgio, Sireno Laura, Antinozzi Cristina, Olson Mark E., Dimauro Ivan, Duranti Guglielmo
Primary Institution: Università degli Studi di Roma “Foro Italico”
Hypothesis
Moringa oleifera leaf extract (MOLE) could efficiently protect C2C12 myoblasts subjected to a pro-oxidant environment.
Conclusion
Moringa oleifera leaf extract can protect C2C12 myoblasts by restoring redox balance and enhancing recovery under oxidative stress.
Supporting Evidence
- MOLE treatment restored the GSH/GSSG ratio and improved total antioxidant capacity.
- MOLE promoted faster wound closure in myoblasts exposed to H2O2.
- H2O2 treatment caused a significant decrease in cell viability and total antioxidant capacity.
Takeaway
Moringa leaves can help muscle cells heal better when they are stressed by harmful substances.
Methodology
C2C12 myoblasts were treated with Moringa oleifera leaf extract and/or hydrogen peroxide, and various assays were conducted to assess cell viability, antioxidant capacity, and wound recovery.
Limitations
The study does not exclude the possibility of isothiocyanate production from glucosinolate metabolism in myoblasts.
Statistical Information
P-Value
p<0.01
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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