rac-4-[4-Cyano-2-(hydroxymethyl)phenyl]-4-(4-fluorophenyl)-4-hydroxy-N,N-dimethylbutanaminium hemifumarate
2011
Crystal Structure of a Citalopram Derivative
publication
Evidence: high
Author Information
Author(s): Wang En-Ju, Chen Guang-Ying
Primary Institution: Hainan Normal University
Conclusion
The crystal structure of the fumaric acid salt of citalopram diol has been successfully determined.
Supporting Evidence
- The cation and anion in the crystal structure are linked by hydrogen bonds.
- The dihedral angle between the two benzene rings is nearly perpendicular.
- Disordered carbon atoms in the structure were refined with specific occupancies.
Takeaway
The researchers made a special salt from citalopram, which is a medicine for depression, to help it form crystals more easily.
Methodology
The compound was prepared by mixing citalopram diol and fumaric acid in ethanol, and crystals were obtained through slow volatilization.
Digital Object Identifier (DOI)
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