Enhanced anti-proliferative action of busulphan by quercetin on the human leukaemia cell line K562
1989
Combining Quercetin and Busulphan to Fight Leukaemia
Sample size: 3
publication
Evidence: moderate
Author Information
Author(s): R. Hoffman, L. Graham, E.S. Newlands
Primary Institution: Cancer Research Campaign Laboratories, Department of Medical Oncology, Charing Cross Hospital
Hypothesis
Does quercetin enhance the anti-proliferative effects of busulphan on K562 leukaemia cells?
Conclusion
Quercetin combined with busulphan shows a synergistic effect in reducing the proliferation of K562 leukaemia cells.
Supporting Evidence
- Quercetin enhances the anti-proliferative activity of nitrogen mustard.
- K562 cells express an abnormal tyrosine kinase and high levels of PKC.
- Combining quercetin and busulphan resulted in a combination index indicating synergism.
Takeaway
Mixing two medicines, quercetin and busulphan, can help fight leukaemia better than using just one of them.
Methodology
K562 cells were treated with various concentrations of busulphan, quercetin, or both, and cell viability was measured after 5 days.
Limitations
The maximum tolerated dose for quercetin in humans has not been determined.
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