Role of genetic polymorphisms in tumour angiogenesis
2002
Genetic Variations and Tumor Blood Vessel Growth
publication
Evidence: moderate
Author Information
Author(s): Balasubramanian S P, Brown N J, Reed M W R
Primary Institution: University of Sheffield
Hypothesis
Polymorphisms in genes encoding angiogenic factors may influence cancer susceptibility and severity.
Conclusion
Genetic variations in angiogenesis-related genes could help explain differences in tumor growth and progression among individuals.
Supporting Evidence
- Angiogenesis is crucial for tumor growth and metastasis.
- Polymorphisms can affect gene expression and protein function.
- Certain genetic variations may influence cancer treatment outcomes.
Takeaway
Some people have different versions of genes that can affect how tumors grow blood vessels, which might make them more or less likely to get cancer.
Methodology
The article reviews existing literature on genetic polymorphisms related to angiogenesis in cancer.
Limitations
The review focuses only on functionally important polymorphisms and does not cover all genetic variations.
Digital Object Identifier (DOI)
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