IL-1beta Gene Polymorphism and Cachexia in Gastric Cancer
Author Information
Author(s): Zhang Dianliang, Zheng Hongmei, Zhou Yanbing, Tang Xingming, Yu Baojun, Li Jieshou
Primary Institution: Affiliated Hospital of Qingdao University Medical College
Hypothesis
IL-1B gene polymorphisms are associated with the development of cachexia in patients with locally advanced gastric cancer.
Conclusion
The IL-1B+3954 T allele is a major risk factor for cachexia in patients with locally advanced gastric cancer.
Supporting Evidence
- Patients with cachexia had a higher prevalence of the IL-1B+3954 T allele.
- Logistic regression showed an odds ratio of 2.512 for the IL-1B+3954 CT genotype in relation to cachexia.
- No significant differences were found in other IL-1 gene polymorphisms between cachexia and non-cachexia groups.
Takeaway
This study found that a specific gene variant is linked to weight loss in stomach cancer patients, which is a serious condition called cachexia.
Methodology
The study involved 214 patients and 230 healthy volunteers, analyzing gene polymorphisms using DNA from blood samples.
Potential Biases
Potential bias due to the exclusion of certain populations and lack of dietary history.
Limitations
The study did not evaluate the protein loss of subjects, which could affect the results.
Participant Demographics
All participants were Chinese Han individuals.
Statistical Information
P-Value
0.018
Confidence Interval
1.180 – 5.347
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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