Royal Jelly Protects Against Cisplatin-Induced Damage in Rats
Author Information
Author(s): Karadeniz Ali, Simsek Nejdet, Karakus Emre, Yildirim Serap, Kara Adem, Can Ismail, Kisa Fikrullah, Emre Habib, Turkeli Mehmet
Primary Institution: University of Atatürk
Hypothesis
Royal jelly can mitigate oxidative stress and apoptosis in the liver and kidneys of rats treated with cisplatin.
Conclusion
Royal jelly may help reduce liver and kidney damage caused by cisplatin treatment.
Supporting Evidence
- Royal jelly significantly reduced levels of lipid peroxidation in the liver and kidneys.
- Treatment with royal jelly increased antioxidant enzyme activities in the tissues.
- Histological examination showed less degeneration in the liver and kidneys of rats treated with royal jelly and cisplatin.
Takeaway
This study shows that royal jelly can help protect rats' livers and kidneys from damage caused by a cancer drug called cisplatin.
Methodology
Twenty-four Sprague Dawley rats were divided into four groups and treated with saline, cisplatin, royal jelly, or a combination of royal jelly and cisplatin, followed by biochemical and histological analyses.
Limitations
The study was conducted on rats, and results may not directly translate to humans.
Participant Demographics
Adult female Sprague Dawley rats, 180 ± 20 g, aged 6–8 weeks.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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