Mechanisms of Vitamins Inhibiting Ferroptosis
2024
How Vitamins Help Prevent Ferroptosis
publication
10 minutes
Evidence: moderate
Author Information
Author(s): Zhang Meng, Chen Xin, Zhang Yumei
Primary Institution: Yangzhou University
Hypothesis
Vitamins can inhibit ferroptosis, a form of cell death linked to various diseases.
Conclusion
Vitamins A, B, C, D, E, and K have mechanisms that can inhibit ferroptosis and may provide therapeutic benefits for related diseases.
Supporting Evidence
- Vitamins can reduce lipid peroxidation, which is a key factor in ferroptosis.
- Vitamin A can enhance the expression of genes that protect against ferroptosis.
- Vitamin D activates receptors that help inhibit ferroptosis in kidney cells.
- Vitamin E is known to prevent lipid peroxidation and protect against ferroptosis.
- Vitamin K has been shown to directly trap lipid radicals, reducing ferroptosis.
- Vitamin B6 can restore levels of important antioxidants in cells, helping to prevent ferroptosis.
- Vitamin C has antioxidant properties that may help protect cells from ferroptosis.
Takeaway
Vitamins are like superheroes for our cells, helping to stop a bad kind of cell death called ferroptosis that can make us sick.
Methodology
This review summarizes the mechanisms by which various vitamins inhibit ferroptosis based on existing literature.
Limitations
Most studies are based on cell and animal models, with limited large-scale clinical research.
Digital Object Identifier (DOI)
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