Genetic Effects of FTO and MC4R Polymorphisms on Body Mass in Constitutional Types
Author Information
Author(s): Cha Seongwon, Koo Imhoi, Park Byung L., Jeong Sangkyun, Choi Sun M., Kim Kil S., Shin Hyoung D., Kim Jong Y.
Primary Institution: Korea Institute of Oriental Medicine
Hypothesis
How do FTO and MC4R polymorphisms affect body mass in different Sasang constitutional types?
Conclusion
FTO and MC4R polymorphisms are linked to weight gain, with FTO variants also influencing weight loss after lifestyle changes.
Supporting Evidence
- FTO and MC4R polymorphisms were associated with increased BMI in the study population.
- After a lifestyle intervention, individuals with certain FTO haplotypes lost more waist-to-hip ratio.
- Different trends in weight gain were observed among individuals of different Sasang constitutional types.
Takeaway
Some genes can make people gain weight, and different types of people might be affected differently by these genes.
Methodology
The study involved genetic analysis of FTO and MC4R polymorphisms in two Korean populations, assessing their association with BMI and waist-to-hip ratio before and after a lifestyle intervention.
Potential Biases
The study may have bias due to the higher number of female participants and the specific population sampled from obesity clinics.
Limitations
The study had a small number of subjects from certain constitutional types, which may limit the generalizability of the findings.
Participant Demographics
The study included 1370 Koreans, with a higher proportion of women, and categorized them into different Sasang constitutional types.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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