Comparing Raman Spectroscopy-Based Artificial Intelligence to High-Definition White Light Endoscopy for Endoscopic Diagnosis of Gastric Neoplasia: A Feasibility Proof-of-Concept Study
2024

Comparing AI and Endoscopy for Diagnosing Stomach Cancer

Sample size: 20 publication 10 minutes Evidence: moderate

Author Information

Author(s): Soong Tse Kiat, Kim Guo Wei, Chia Daryl Kai Ann, So Jimmy Bok Yan, Lee Jonathan Wei Jie, Shabbbir Asim, Lum Jeffrey Huey Yew, Soon Gwyneth Shook Ting, Ho Khek Yu

Primary Institution: National University Hospital, Singapore

Hypothesis

Can Raman spectroscopy-based AI provide comparable diagnostic performance to high-definition white light endoscopy for gastric lesions?

Conclusion

The AI-enabled Raman spectroscopy performed similarly to expert endoscopists using high-definition white light endoscopy in diagnosing gastric lesions.

Supporting Evidence

  • The AI system achieved 100% sensitivity and 80% specificity in diagnosing gastric lesions.
  • Both diagnostic methods showed similar accuracy rates of around 90%.
  • The study was conducted in a real-world clinical setting, enhancing its relevance.

Takeaway

This study shows that a new AI tool can help doctors quickly and accurately identify stomach problems, just like experienced doctors do.

Methodology

A randomized double-arm feasibility proof-of-concept trial comparing AI-enabled Raman spectroscopy with high-definition white light endoscopy in patients with suspected gastric neoplasia.

Potential Biases

Potential bias due to the non-blinding of participants and endoscopists to the assigned intervention.

Limitations

The study had a small sample size and was conducted during the pandemic, which limited participant recruitment.

Participant Demographics

Mean age of 71.7 years; 57.1% male; 90.5% Chinese.

Statistical Information

P-Value

1.00

Confidence Interval

95% CI: 40–100%

Statistical Significance

p = 1.00

Digital Object Identifier (DOI)

10.3390/diagnostics14242839

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