Teucrium Plant Species as Natural Sources of Anticancer Compounds
Author Information
Author(s): Stankovic Milan S., Curcic Milena G., Zizic Jovana B., Topuzovic Marina D., Solujic Slavica R., Markovic Snezana D.
Primary Institution: Department of Biology and Ecology, Faculty of Science, University of Kragujevac
Hypothesis
This study aims to evaluate some Teucrium species as new potential natural sources of effective antiproliferative and antioxidant agents.
Conclusion
Teucrium species extracts have strong antiproliferative and proapoptotic activities on the HCT-116 colon cancer cell line.
Supporting Evidence
- Teucrium extracts significantly reduced cell viability in a dose-dependent manner.
- The highest cytotoxic activity was observed in T. chamaedrys with an IC50 of 5.48 × 10−9 μg/mL.
- After 72 hours, T. arduini showed the best cytotoxic activity with an IC50 of 0.37 μg/mL.
- All extracts caused typical apoptotic changes in HCT-116 cells.
- Phenolic compounds in Teucrium species contribute to their anticancer effects.
Takeaway
Some plants called Teucrium can help fight cancer by making cancer cells die and stopping them from growing.
Methodology
The study used methanolic extracts from different Teucrium species and tested their effects on the HCT-116 human colon cancer cell line using MTT assay and fluorescence microscopy.
Limitations
The study did not test the effects of Teucrium species extracts on normal cell lines.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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