Measles Immunity in Infants in Maputo, Mozambique
Author Information
Author(s): Jani Jagrati, Holm-Hansen Carol, Mussá Tufária, Zango Arlinda, Manhiça Ivan, Bjune Gunnar, Jani Ilesh
Primary Institution: Instituto Nacional de Saúde, Mozambique
Hypothesis
What is the level of measles immunity among six- and nine-month-old infants in Maputo City, Mozambique?
Conclusion
The study suggests a need to re-evaluate the effectiveness of the measles immunization policy in the current epidemiological scenario.
Supporting Evidence
- 82.4% of six-month-old children lost maternal antibodies.
- 84.2% seroconversion rate was observed after vaccination.
- 30.5% of nine-month-old children had antibodies before vaccination.
Takeaway
This study looked at how many babies in Maputo have protection against measles and found that many lose their mother's antibodies before they can get vaccinated.
Methodology
A cross-sectional study was conducted to screen six- and nine-month-old children for measles-specific antibodies in oral fluid.
Potential Biases
Potential bias due to reliance on maternal reports for vaccination history.
Limitations
The study's cross-sectional design limits the ability to establish causation and the accuracy of maternal vaccination status was not confirmed.
Participant Demographics
Infants aged six and nine months, with mothers aged 16 to 45 years.
Statistical Information
P-Value
p<0.001
Confidence Interval
95% CI 85.2–100.0
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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