Using MCM-48 Mesoporous Silica to Deliver Metformin for Diabetes
Author Information
Author(s): Sha’at Mousa, Ignat Maria, Sacarescu Liviu, Spac Adrian Florin, Barsan (Bujor) Alexandra, Ghizdovat Vlad, Nazaretian Emanuel, Dumitras Catalin, Agop Maricel, Rusu Cristina Marcela, Ochiuz Lacramioara, Shao Xiangli
Primary Institution: ”Grigore T. Popa” University of Medicine and Pharmacy Iasi, Romania
Hypothesis
MCM-48, with its unique pore structure and high loading capacity, will provide an ideal matrix for controlling metformin release, improving its therapeutic performance.
Conclusion
MCM-48 mesoporous silica effectively enhanced metformin delivery, offering a controlled release profile well-suited for type 2 diabetes management.
Supporting Evidence
- SEM-EDX confirmed the uniform distribution of silicon and oxygen in MCM-48.
- Nitrogen adsorption analyses showed a high specific surface area of 1325.96 m²/g for unloaded MCM-48.
- The loading capacities were 59.788 mg/g and 160.978 mg/g for metformin at different concentrations.
- In vitro dissolution studies showed a biphasic release profile with cumulative releases of 92.63% and 82.64% after 14 hours.
Takeaway
This study shows that a special type of silica can help deliver a diabetes medicine better, making it work more effectively over time.
Methodology
MCM-48 was synthesized using a sol–gel method, characterized, and loaded with metformin hydrochloride solutions at different concentrations, followed by in vitro dissolution studies.
Statistical Information
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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