Kupffer cells of cirrhotic rat livers sensitize colon cancer cells to Fas-mediated apoptosis
2001
Kupffer Cells in Cirrhotic Livers Help Fight Colon Cancer
publication
Author Information
Author(s): Song E, Chen J, Ouyang N, Wang M, Exton M S, Heemann U
Primary Institution: University Hospital Essen
Hypothesis
Activated Kupffer cells from cirrhotic rat livers influence the hepatic colonization and apoptosis of colon cancer cells.
Conclusion
Kupffer cells in cirrhotic livers sensitize metastatic colon cancer cells to FasR-mediated apoptosis.
Supporting Evidence
- Treatment with conditioned media from Kupffer cells significantly reduced the incidence of hepatic colonization of colon cancer cells.
- RCN-9 cells were sensitized to TIL-mediated killing after treatment with cirrhotic KCM.
- Cirrhotic KCM increased recombinant Fas ligand-induced apoptosis of RCN-9 cells.
Takeaway
In sick livers, special cells help make cancer cells easier to kill by the body's immune system.
Methodology
The study used a rat colon cancer cell line and evaluated the effects of conditioned media from Kupffer cells on cancer cell behavior.
Digital Object Identifier (DOI)
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