Effects of Lipopolysaccharide and Meloxicam on Donkey Heart Function
Author Information
Author(s): Mendoza Francisco J., Buzon-Cuevas Antonio, Aguilera-Aguilera Raul, Gonzalez-De Cara Carlos A., De Las Heras Adelaida, Perez-Ecija Alejandro
Primary Institution: Department of Animal Medicine and Surgery, University of Cordoba, Spain
Hypothesis
Experimentally induced endotoxemia will cause deleterious changes in blood pressure and cardiac parameters, and that meloxicam could avoid these effects.
Conclusion
Meloxicam administration can prevent and alleviate the harmful effects of endotoxemia on cardiac function in donkeys.
Supporting Evidence
- LPS infusion caused an increase in cardiac troponin I concentrations.
- Meloxicam administration prevented the increase in cTnI concentrations.
- LPS infusion led to hypotension and decreased central venous pressure.
- Meloxicam ameliorated the decrease in cardiac output and stroke volume.
- Most hemodynamic derangements were prevented by meloxicam.
Takeaway
When donkeys get sick from infections, their hearts can struggle. Giving them a medicine called meloxicam helps their hearts work better.
Methodology
The study induced endotoxemia in donkeys using lipopolysaccharide infusion and monitored hemodynamic and cardiac parameters before and after meloxicam administration.
Potential Biases
Potential bias from the single operator performing echocardiographic measurements.
Limitations
The study involved a small sample size and was conducted in a controlled experimental setting, which may not fully represent clinical conditions.
Participant Demographics
Six healthy adult non-pregnant jennies, average age 7.6 years.
Statistical Information
P-Value
p<0.05
Confidence Interval
95% CI of the mean between 0.0071 and 0.0158 ng/mL for cTnI concentrations.
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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