Right Ventricular Dyssynchrony and Pulmonary Arterial Hypertension
Author Information
Author(s): Lindholm Anthony, Kjellström Barbro, Rådegran Göran, Arheden Håkan, Ostenfeld Ellen
Primary Institution: Lund University, Lund, Sweden
Hypothesis
Is right ventricular dyssynchrony a prognostic marker for transplantation-free survival in pulmonary arterial hypertension?
Conclusion
Right ventricular dyssynchrony assessed from three views is associated with outcomes in pulmonary arterial hypertension, while assessments from one or two views and post systolic contraction are not.
Supporting Evidence
- An increase in RV dyssynchrony by 1% was associated with a 10% increased risk of lung transplantation or death.
- Patients with events had lower left ventricular end-diastolic and end-systolic volumes compared to those without events.
- PSC was present in about half of the patients, but did not correlate with transplantation-free survival.
Takeaway
This study found that looking at the heart from three different angles can help doctors predict how long patients with a certain lung disease will live without needing a transplant.
Methodology
Patients with pulmonary arterial hypertension underwent cardiac magnetic resonance imaging to assess right ventricular dyssynchrony and post systolic contraction from multiple views.
Potential Biases
Potential selection bias as severely ill patients may not have been referred for CMR.
Limitations
The study is retrospective, may have selection bias, and only 62 of 101 patients had all three views due to protocol changes.
Participant Demographics
Patients were predominantly women (66%) with a mean age of 58 years.
Statistical Information
P-Value
0.03
Confidence Interval
1.01–1.20
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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