The Role of MMP-14, TIMP-2, and MMP-2 in Breast Cancer Prognosis
Author Information
Author(s): Têtu Bernard, Brisson Jacques, Wang Chang Shu, Lapointe Hélène, Beaudry Geneviève, Blanchette Caty, Trudel Dominique
Primary Institution: Laval University
Hypothesis
The individual expression of MMP-14, TIMP-2, and MMP-2 or their balance may help to predict breast cancer prognosis.
Conclusion
MMP-14 was the most significant factor associated with breast cancer prognosis, indicating poor overall survival when adjusted for clinical factors.
Supporting Evidence
- High MMP-14 expression predicted a significantly shorter overall survival.
- The survival was worst for patients with high MMP-2/high MMP-14/low TIMP-2.
- The study included 539 breast cancer cases without distant metastasis at diagnosis.
Takeaway
This study found that a protein called MMP-14 can help doctors understand how serious a breast cancer case might be.
Methodology
MMP-2, MMP-14, and TIMP-2 expression was evaluated using 35S mRNA in situ hybridization on paraffin material from breast cancer samples.
Limitations
The prognostic significance of MMP-14 was not independent of HER-2/neu and uPA, which may limit its usefulness as a prognostic marker.
Participant Demographics
Patients aged 29 to 72 years, with a median follow-up of 9.2 years.
Statistical Information
P-Value
0.031
Statistical Significance
p = 0.031
Digital Object Identifier (DOI)
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