SSMap: A new UniProt-PDB mapping resource for the curation of structural-related information in the UniProt/Swiss-Prot Knowledgebase
2008
SSMap: A New Resource for Mapping UniProt to PDB
publication
Evidence: high
Author Information
Author(s): David Fabrice, Yip Yum
Primary Institution: Swiss Institute of Bioinformatics
Hypothesis
Can a new mapping resource improve the accuracy of UniProt-PDB cross-references?
Conclusion
SSMap provides a high-quality, independent mapping resource that enhances the accuracy and coverage of UniProt-PDB mappings.
Supporting Evidence
- SSMap shares about 80% of mappings with other mapping sources.
- SSMap is the first isoform sequence-specific mapping resource.
- SSMap is kept up-to-date with each UniProt release.
Takeaway
SSMap helps scientists find the right connections between protein sequences and their 3D structures, making it easier to understand how proteins work.
Methodology
SSMap was created by reconstructing sequences from PDB structures and performing a systematic comparison with existing mapping resources.
Limitations
The study acknowledges that some mappings were deliberately excluded due to ambiguities and uncertainties.
Digital Object Identifier (DOI)
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