An annotation infrastructure for the analysis and interpretation of Affymetrix exon array data
2007
Annotation Infrastructure for Affymetrix Exon Array Data
Sample size: 6
publication
Evidence: high
Author Information
Author(s): Michał J Okoniewski, Tim Yates, Siân Dibben, Crispin J Miller
Primary Institution: Cancer Research UK, Paterson Institute for Cancer Research, The University of Manchester
Conclusion
The X:MAP database and exonmap R package provide a comprehensive solution for analyzing Affymetrix exon array data.
Supporting Evidence
- X:MAP is designed to support fine-grained analysis of exon array data.
- The system provides gene-, transcript-, and exon-level summaries and visualization tools.
- The study identified 11,109 differentially expressed probesets from two cell lines.
Takeaway
This study created tools to help scientists understand complex data from gene studies better. It's like building a special map to find out how genes work.
Methodology
The study developed an annotation database (X:MAP) and a BioConductor/R package (exonmap) for analyzing exon array data.
Limitations
The study may miss alternative splicing events not represented in current databases.
Digital Object Identifier (DOI)
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