The YPLGVG sequence of the Nipah virus matrix protein is required for budding
2008
Nipah Virus Matrix Protein and Its Role in Budding
publication
Evidence: moderate
Author Information
Author(s): Jared Patch, Ziying Han, Sarah E. McCarthy, Lianying Yan, Lin-Fa Wang, Ronald N. Harty, Christopher C. Broder
Primary Institution: Uniformed Services University
Hypothesis
The YPLGVG sequence of the Nipah virus matrix protein is required for budding.
Conclusion
The YPLGVG motif within the NiV M protein is essential for M budding, and its mutation leads to nuclear localization of the protein.
Supporting Evidence
- The YPLGVG sequence is critical for the budding ability of the Nipah virus matrix protein.
- Mutation of the YPLGVG sequence resulted in nuclear localization of the matrix protein.
- The study suggests that the YPLGVG motif may interact with cellular proteins to facilitate budding.
Takeaway
The Nipah virus has a special part in its protein that helps it leave the cell, and if that part is changed, the virus can't leave properly.
Methodology
The study used site-directed mutagenesis to analyze the role of the YPLGVG sequence in the matrix protein of Nipah virus.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website