Coronary Perfusion Pressure and Outcomes in Infant Heart Surgery
Author Information
Author(s): Ge Tongkai, Luo Dandong, Wang Qiuji, Chen Jimei, Huang Huanlei, Zhang Chongjian
Primary Institution: Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences
Hypothesis
The CPP level has a nonlinear relationship with in-hospital outcomes after congenital cardiac surgery.
Conclusion
CPP levels exhibited a nonlinear relationship with poor in-hospital outcomes, with both low and high levels being associated with adverse outcomes.
Supporting Evidence
- Prolonged recovery was associated with both low and high CPP levels.
- The inflection point of CPP level for prolonged recovery was 47 mm Hg.
- Mortality rate among participants was 1%.
- Low CPP levels were linked to a higher risk of prolonged hospital stay.
- High CPP levels were also associated with adverse outcomes.
Takeaway
If the blood pressure in the heart is too low or too high after surgery, it can make babies sicker. Doctors need to keep it just right to help them recover.
Methodology
Retrospective analysis of 296 infant patients who underwent congenital cardiac surgery, with logistic regression and restricted cubic splines used to evaluate associations.
Limitations
The study relied on a single time point for hemodynamic variables, which may not capture the full picture of patient outcomes.
Participant Demographics
Infant patients aged 31–120 days who underwent congenital cardiac surgery.
Statistical Information
P-Value
p<0.001
Confidence Interval
95% CI 1.48–9.35 and 95% CI 2.32–15.72
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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