rac-Diethyl 6-hydroxy-4-[(2-hydroxyethyl)amino]-6-methyl-2-phenylcyclohex-3-ene-1,3-dicarboxylate
2011
Study of a Chiral Compound with Biological Activity
publication
Evidence: moderate
Author Information
Author(s): Maharramov Abel M., Ismiyev Arif I., Rashidov Bahruz A.
Primary Institution: Baku State University
Hypothesis
The reactions of β-cycloketoles with ethanolamine may lead to valuable compounds of practical use.
Conclusion
The crystal structure of the compound shows significant hydrogen bonding interactions.
Supporting Evidence
- The compound is chiral with three stereogenic centers.
- The crystal packing displays intermolecular hydrogen bonding.
- The ethyl fragment of the ethoxycarbonyl group is disordered.
Takeaway
Scientists studied a special compound that can be used in medicine, and they found that it has a unique structure with special bonds.
Methodology
The compound was synthesized by dissolving rac-Diethyl-4-hydroxy-4-methyl-6-oxo-2-phenyl-1,3-dicarboxylate and monoethanolamine in ethanol and stirring at high temperature.
Limitations
The reactions of β-cycloketoles with ethanolamine remain unexplored.
Digital Object Identifier (DOI)
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