Expression of vascular endothelial growth factor (VEGF) and its mRNA in uterine cervical cancers
1999
VEGF and Its Role in Cervical Cancer
publication
Author Information
Author(s): Fujimoto J, Sakaguchi H, Hirose R, Ichigo S, Tamaya T
Primary Institution: Gifu University School of Medicine
Hypothesis
The study investigates the relationship between vascular endothelial growth factor (VEGF) expression and the progression of uterine cervical cancer.
Conclusion
Higher levels of VEGF165 and VEGF121 are associated with advanced stages of cervical adenocarcinomas, suggesting their role in cancer progression.
Supporting Evidence
- VEGF expression was predominantly found in cancer cells.
- VEGF levels were significantly higher in some advanced adenocarcinomas compared to normal cervices.
- The study analyzed the correlation between VEGF expression and microvessel density.
Takeaway
This study found that certain proteins called VEGF can help cervical cancer grow and spread, especially in more advanced cases.
Methodology
The study used immunohistochemical staining, Western blot analysis, and RT-PCR to analyze VEGF expression and microvessel density.
Digital Object Identifier (DOI)
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