Case of Severe Hypotension from Amlodipine and Losartan Overdose Treated with Metaraminol
Author Information
Author(s): James O. M. Plumb, Craig Stewart, Michael Eddleston, Thearina de Beer
Primary Institution: Nottingham University Hospitals Trust
Hypothesis
Can metaraminol be an effective treatment for severe hypotension caused by combined amlodipine and losartan overdose?
Conclusion
Metaraminol infusion may be beneficial in treating severe cases of calcium channel blocker and angiotensin II receptor antagonist toxicity when other treatments fail.
Supporting Evidence
- Metaraminol was the only treatment that significantly improved the patient's blood pressure.
- The patient had taken a large overdose of losartan and amlodipine.
- Conventional treatments failed to stabilize the patient's condition.
Takeaway
A woman took too many blood pressure pills and had very low blood pressure. A medicine called metaraminol helped her feel better when other treatments didn't work.
Methodology
Case report detailing the treatment of a patient with severe hypotension due to overdose.
Limitations
Only one case is reported, limiting generalizability.
Participant Demographics
50-year-old female with a history of type 2 diabetes, hypertension, and morbid obesity.
Digital Object Identifier (DOI)
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