Comparing Oral Fluconazole and Intravaginal Clotrimazole for Vaginal Candidiasis
Author Information
Author(s): Hiroshige Mikamo, Koji Izumi, Kunihiko Ito, Teruhiko Tamaya
Primary Institution: Gifu University
Hypothesis
Is oral fluconazole more effective than intravaginal clotrimazole in treating vaginal candidiasis?
Conclusion
Oral fluconazole is effective for treating vaginal candidiasis, and a single dose may be a viable treatment option.
Supporting Evidence
- 88% of women treated with 50 mg of oral fluconazole daily for 6 days had Candida eradicated at short-term assessment.
- 92% clinical effectiveness was observed in the same group at short-term assessment.
- Treatment-related side effects were not found in any group.
Takeaway
This study looked at how well two different medicines work for a yeast infection in women. It found that one medicine, fluconazole, works really well.
Methodology
150 women with vaginal candidiasis were randomized to receive different treatment regimens and assessed at short-term and long-term intervals.
Limitations
The small number of patients may limit the statistical power of the study.
Participant Demographics
Mean age of participants was 32.5 years, with a range of 18-54 years.
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