Comparison of 11C-methionine and 18FDG in Rats
Author Information
Author(s): Svorad Štolc, Lucia Jakubíková, Ivica Kukurová
Primary Institution: Biont, Inc.
Hypothesis
How do 11C-methionine and 18FDG distribute in the bodies of intact Wistar rats?
Conclusion
The study found that 11C-methionine accumulates significantly in the liver, spleen, and colon, while 18FDG shows high accumulation in the Harderian glands and heart.
Supporting Evidence
- 11C-methionine accumulated most in the liver, spleen, and colon.
- 18FDG showed high accumulation in the Harderian glands, heart, brain, and colon.
- The study provides reference values for future microPET studies.
Takeaway
This study looked at how two different substances behave in rats' bodies, finding that one gathers in the liver and spleen while the other collects in the glands and heart.
Methodology
Male Wistar rats were scanned using microPET after intravenous administration of 11C-methionine and 18FDG, with measurements taken at various time points.
Limitations
The reliability of 18FDG accumulation data in the kidneys was limited due to a low number of measurements.
Participant Demographics
Male Wistar rats weighing 192–217 g.
Digital Object Identifier (DOI)
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