Genetic Factors Affecting Colorectal Cancer in Hungarians
Author Information
Author(s): Bácsi Krisztián, Hitre Erika, Kósa János P, Horváth Henrik, Lazáry Áron, Lakatos Péter L, Balla Bernadett, Budai Barna, Lakatos Péter, Speer Gábor
Primary Institution: Semmelweis University, Budapest
Hypothesis
Do lactase and calcium-sensing receptor gene polymorphisms influence colorectal cancer incidence and recurrence in the Hungarian population?
Conclusion
LCT 13910 C/T and CaSR A986S polymorphisms may impact the progression and incidence of colorectal cancer.
Supporting Evidence
- LCT CC genotype was associated with increased distant disease recurrence.
- The disease-free survival was reduced for patients with LCT CC genotype.
- CaSR SS genotype was more frequent in patients than in controls.
Takeaway
Some genes can make people more likely to get colorectal cancer, especially if they have certain variations in their DNA.
Methodology
The study involved 538 participants, including 278 colorectal cancer patients and 260 healthy controls, with genetic analysis of specific polymorphisms.
Limitations
The follow-up period was relatively short at 17 months, and detailed evaluation of calcium consumption was lacking.
Participant Demographics
278 colorectal cancer patients (130 female, 148 male) and 260 healthy controls.
Statistical Information
P-Value
p = 0.006 for LCT CC genotype association with distant recurrence
Confidence Interval
95% CI = 1.71–9.58 for LCT polymorphism
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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