Reirradiation of Recurrent Breast Cancer
Author Information
Author(s): Würschmidt Florian, Dahle Jörg, Petersen Cordula, Wenzel Claudia, Kretschmer Matthias, Bastian Christoph
Primary Institution: GMP Radiologie & Radioonkologie im Struensee-Haus, Hamburg, Germany
Hypothesis
Can reirradiation be a safe and effective treatment option for recurrent breast cancer?
Conclusion
Reirradiation of locoregional recurrences of breast cancer showed low to moderate acute toxicity and high local control rates.
Supporting Evidence
- Local progression-free survival at one and two years was 81% and 63%.
- Patients with no distant metastases and at least an R1-resection had a local progression-free survival of 90% after 2 years.
- Partial remission and good symptom relief was achieved in 56% of patients.
Takeaway
This study looked at how giving radiation treatment again to women with breast cancer that came back can help them feel better and live longer, and it found that it can be safe.
Methodology
The study involved 29 patients treated with reirradiation, with data collected prospectively, and included concurrent chemotherapy for some patients.
Limitations
The study had a short median follow-up time and was based on a small sample size from a single community center.
Participant Demographics
The median age of participants was 63 years, with a range from 35 to 82 years.
Digital Object Identifier (DOI)
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