Interactions Between Soil-Transmitted Helminths and Herpes Simplex Virus Type II
Author Information
Author(s): Pillay Roxanne, Naidoo Pragalathan, Duma Zamathombeni, Bhengu Khethiwe N., Mpaka-Mbatha Miranda N., Nembe-Mafa Nomzamo, Mkhize-Kwitshana Zilungile L.
Primary Institution: Mangosuthu University of Technology
Hypothesis
How do soil-transmitted helminths (STHs) affect herpes simplex virus type II (HSV-2) infections in sub-Saharan Africa?
Conclusion
Soil-transmitted helminths may compromise the immune response to herpes simplex virus type II, increasing susceptibility and pathology.
Supporting Evidence
- Soil-transmitted helminths and herpes simplex virus type II are both highly prevalent in sub-Saharan Africa.
- STHs induce anti-inflammatory immune responses that may downregulate pro-inflammatory responses needed to combat HSV-2.
- There is a significant lack of studies on the co-infection of STHs and HSV-2 in humans.
Takeaway
In Africa, worms in the soil can make it easier for a virus that causes genital herpes to infect people and cause more problems.
Methodology
The study reviews existing literature on the interactions between STHs and HSV-2, highlighting gaps in epidemiological and immunological research.
Limitations
There is a lack of epidemiological and immunological studies on STH-HSV-2 co-infections in humans.
Participant Demographics
The study focuses on populations in sub-Saharan Africa, particularly vulnerable groups such as children and women of reproductive age.
Digital Object Identifier (DOI)
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