Non-obese NAFLD and Chronic Kidney Disease Risk
Author Information
Author(s): You Yixian, Pei Xiong, Jiang Wei, Zeng Qingmin, Bai Lang, Zhou Taoyou, Lv Xiaoju, Tang Hong, Wu Dongbo
Primary Institution: Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, China
Hypothesis
Is there a difference in the risk of chronic kidney disease (CKD) between non-obese and obese patients with non-alcoholic fatty liver disease (NAFLD)?
Conclusion
Non-obese NAFLD patients have the same risk of chronic kidney disease as obese NAFLD patients.
Supporting Evidence
- Non-obese NAFLD patients had a CKD incidence of 3.74%.
- Obese NAFLD patients had a CKD incidence of 3.64%.
- Subgroup analyses showed no significant differences in CKD risk based on BMI cut-offs.
Takeaway
This study found that being non-obese with fatty liver disease doesn't mean you're at a higher risk for kidney problems compared to those who are obese.
Methodology
A systematic review and meta-analysis of 15 studies comparing CKD incidence in non-obese and obese NAFLD patients.
Potential Biases
Moderate risk of bias in included studies.
Limitations
Heterogeneity in study designs and potential confounding factors not fully adjusted for.
Participant Demographics
Studies included both Asian and non-Asian populations, with a mix of genders and ages over 18.
Statistical Information
P-Value
0.92
Confidence Interval
[0.72–1.19]
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website