5,6,7-Trichloro-2-methoxy-8-hydroxyquinoline
2011
Structure of 5,6,7-Trichloro-2-methoxy-8-hydroxyquinoline
publication
Author Information
Author(s): Chen Qiu-Mao, Yi Guo-Bin, An Lin-Kun, Feng Xiao-Long
Primary Institution: Guangdong University of Technology
Hypothesis
The title compound was obtained as an unexpected product from an attempt to synthesize a Top1 inhibitor.
Conclusion
The crystal structure reveals that adjacent molecules are connected by hydrogen bonds and π–π stacking interactions, forming an infinite chain.
Supporting Evidence
- The title compound was obtained unexpectedly while trying to synthesize a Top1 inhibitor.
- Adjacent molecules in the crystal structure are connected by hydrogen bonds and π–π stacking interactions.
- The mean plane of the molecule has a very small deviation, indicating a planar conformation.
Takeaway
Scientists made a new compound while trying to create a medicine to fight cancer, and they found that the molecules stick together in a special way.
Methodology
The compound was synthesized through oxidation of 8-Hydroxyquinoline in hydrochloric acid, followed by recrystallization.
Digital Object Identifier (DOI)
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