Involvement of APC and K-ras Mutation in Non-Polypoid Colorectal Tumorigenesis
2000
Role of APC and K-ras Mutations in Colorectal Tumor Development
Sample size: 163
publication
Evidence: moderate
Author Information
Author(s): Umetani N, Sasaki S, Masaki T, Watanabe T, Matsuda K, Muto T
Primary Institution: The University of Tokyo
Hypothesis
The study aims to clarify the role of APC and K-ras mutations in non-polypoid colorectal tumorigenesis.
Conclusion
APC mutations are necessary for the development of non-polypoid carcinomas, while K-ras mutations are not essential.
Supporting Evidence
- The frequency of K-ras mutations in superficial depressed adenomas was lower than in polypoid adenomas.
- K-ras mutation frequency in non-polypoid carcinomas was lower than in polypoid carcinomas.
- APC mutation frequency in superficial depressed adenomas was lower than in polypoid adenomas.
- Polypoid adenomas, polypoid carcinomas, and advanced carcinomas had similar mutation frequencies.
Takeaway
This study looked at how certain gene changes are involved in a type of colon cancer that doesn't start from polyps, finding that one gene change is important while another isn't.
Methodology
DNA from 63 adenomas and 66 submucosally invasive carcinomas was examined for K-ras and APC mutations.
Statistical Information
P-Value
P = 0.018; P = 0.0008
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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