Apoptosis and inflammation
1995
Apoptosis and Inflammation
publication
Author Information
Author(s): C. Haanen, I. Vermes
Primary Institution: Department of Clinical Chemistry, Medical Spectrum Twente, The Netherlands
Hypothesis
Neutrophil apoptosis may represent an important event in the control of inflammation.
Conclusion
Apoptotic cell death plays an important role in inflammatory processes and in the resolution of inflammatory reactions.
Supporting Evidence
- Apoptosis is a form of cell death that does not harm the host and is necessary for normal existence.
- Neutrophils undergo apoptosis during the resolution of inflammation.
- Removal of neutrophils from the inflammatory site without release of granule contents is crucial for cessation of inflammation.
- Various growth factors and cytokines can inhibit or enhance apoptosis in different cell types.
Takeaway
When cells die in a controlled way, it's called apoptosis, and it helps stop inflammation without causing harm.
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