Sodium phenylacetate enhances the inhibitory effect of dextran derivative on breast cancer cell growth in vitro and in nude mice
2001
Combining Sodium Phenylacetate and Dextran Derivative to Fight Breast Cancer
publication
Evidence: moderate
Author Information
Author(s): Benedetto M Di, Kourbali Y, Starzec A, Vassy R, Jozefonvicz J, Perret G, Crepin M, Kraemer M
Primary Institution: Université Paris 13
Hypothesis
Can the combination of sodium phenylacetate and a dextran derivative enhance the inhibition of breast cancer cell growth?
Conclusion
The combination of sodium phenylacetate and the dextran derivative significantly inhibits breast tumor growth without toxicity.
Supporting Evidence
- Sodium phenylacetate inhibited breast cancer cell proliferation by inducing apoptosis.
- The combination of sodium phenylacetate and the dextran derivative reduced tumor growth by 83%.
- The treatments showed no toxicity in the mice.
Takeaway
This study found that using two different treatments together can help stop breast cancer cells from growing better than using them alone.
Methodology
The study tested the effects of sodium phenylacetate and a dextran derivative on breast cancer cells in lab conditions and in mice.
Digital Object Identifier (DOI)
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